Spravato (Esketamine) Treatment

We are a REMS Certified Spravato Treatment Center

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SPRAVATO (esketamine) nasal spray treatment is a revolutionary new approach to managing severe depression in adults with treatment-resistant depression and adults with major depressive disorder (MDD) with suicidal thoughts or actions. If you are struggling with depression and feel like you have tried everything, Spravato (esketamine) nasal spray treatment could be the solution you’ve been looking for.


What is Spravato?

Spravato (esketamine) spray is a new approach to treating severe depression in adults. It is a nasal spray containing esketamine, a form of ketamine, a medication that has been used as an anesthetic for several decades. The FDA approved nasal esketamine in 2019 for use in adult patients with treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal thoughts or tendencies.


How does Spravato Treatment Work?

Spravato esketamine nasal spray treatment targets a different neurotransmitter system in the brain than traditional antidepressants. It binds to the N-methyl-D-aspartate (NMDA) receptor, which regulates mood and emotions. This binding leads to increased production of certain chemicals in the brain, which can help improve mood and reduce symptoms of depression. It is the first of its kind, treating those suffering from severe depression who previously had few options. The treatment is given in a REMS-certified healthcare provider’s office, and patients are closely monitored during and after treatment to ensure their safety.


Who is a candidate for Spravato therapy?

Spravato therapy may be an option for adults diagnosed with treatment-resistant depression (TRD) or major depressive disorder (MDD) with acute suicidal ideation or behavior. Candidates for Spravato therapy must have tried at least two antidepressant treatments for adequate time without relief from their symptoms. 

Spravato is not recommended for individuals with aneurysmal vascular disease, a history of intracerebral hemorrhage, or sensitivity to ketamine or esketamine. Women who are pregnant or may become pregnant and those aged 65 and older are not candidates for this treatment.


What is the Spravato Treatment Schedule?

The Spravato therapy schedule involves an initial phase of twice-weekly treatments for the first four weeks, followed by a maintenance phase of once-weekly treatments for at least four weeks. Each treatment consists of administering the medication through a nasal spray under the supervision of a healthcare professional. The patient must remain under observation for at least two hours after each treatment, and the healthcare provider will monitor the patient’s blood pressure and pulse during this time. The duration of Spravato treatment may vary depending on the patient’s response and circumstances. It’s essential to follow the treatment schedule as prescribed by the healthcare provider, as discontinuing treatment too soon may reduce the effectiveness of the medication.


Spravato Treatment Center in Phoenix, AZ

As a REMS Certified Spravato Treatment Center in Phoenix, our medical providers are trained in the proper way to administer and care for our patients during their treatment. We provide a comfortable, relaxing, and private environment for our patients during their treatment, with dedicated rooms designed to ensure their safety and well-being. If you live in the Phoenix area and are interested in Spravato intranasal esketamine therapy for treatment-resistant depression or major depressive disorder, schedule an appointment today. Our medical providers can help determine if Spravato treatment is right for you.


Common Questions About Spravato (Esketamine) Treatment

Is Spravato covered by insurance?

Yes! Most major insurance companies cover Spravato esketamine nasal treatment for depression. Currently, esketamine treatment is approved for people with treatment-resistant depression. That means you've tried at least two other antidepressants (for at least six weeks each) and haven't experienced remission or at least a 50% improvement in mood. Our caring clinic staff will work with your insurance provider to handle all the insurance on your behalf. Your out-of-pocket cost will depend on your specific insurance co-pay, but thanks to Spravato savings programs, you may pay as little as $10 per treatment.

How is Spravato given?

Spravato medication is given in the form of a nasal spray. At the appointment you will self-administer 2-3 sprays in your nostril depending on your dose. Then, you will relax in our private, comfortable room where our medical staff will monitor you for any potential side effects. Finally, you will want to have someone available to drive you home after your treatment.

What are the potential side effects of Spravato?

Like all medications, Spravato can cause potential side effects. The most commonly reported side effects of Spravato include dizziness, nausea, and feeling disoriented. Other side effects may include increased blood pressure, dissociation, sedation, anxiety, and headache. It is important to note that not all patients will experience these side effects, and most side effects will resolve on their own shortly after treatment. Our medical providers closely monitor patients for potential side effects during and after each Spravato treatment session to ensure their safety and well-being.

Is Spravato the same as ketamine infusions?

SPRAVATO and IV ketamine are not the same medications, although they are chemically related. Only SPRAVATO® has been extensively studied in controlled clinical trials that resulted in FDA approval for use in adults with treatment-resistant depression and to alleviate depressive symptoms in adults with major depressive disorder who have acute suicidal thoughts or behavior. The effectiveness and safety of IV ketamine in treating depression and suicidal ideation has not been as thoroughly studied as SPRAVATO.

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